Nearly abstract hymenium of a yet unknown #lichen I am working on tonight. #microscopy
Nearly abstract hymenium of a yet unknown #lichen I am working on tonight. #microscopy
Managed to capture this goober at 400x magnification with my #microscope. The water sample is from my fish fry #aquarium. Do any #microbiology #microscopy friends know what this tiny animal is?
Id want to keep the microscope and staining as an active part out of the game though. So you are not a microscopist who follows a single bacterium and applies different stains, because it would limit believably and realism if the game world would be only on a microscope slide.
The #staining and #imaging techniques would serve to bring across the magic of this hidden universe that becomes so vivid when you apply the right stains while also allowing for different game play tactics. I feel like there is nothing more wonderful and magical to see this world appear buzzing with life.
besides learning a lot about #microbiology and #microscopy #imaging i cant imagine anything more engaging and thrilling for a game.
You dont need to know anything about this stuff because if you see methods, principles and details of the micro physiology? in action they are easily understood and used.
I certainly dont have the programming skills to do this, besides waiting on the seed funding for my #startup anyway. But if i had the time and funding id love to do this. You could even go and make it an #mmorpg .
The whole game with its dynamics and vase skills / abilities is literally already there, it just need to be captured.
#gamedesign #science #research #biology
As you try to stay alive and evolve you decide a flagellum is the next best step to escape the certain death of an amoeba or maybe an endospore that while it wouldnt protect you from being eaten, it would be indigestible and allow you to survive an attack. Maybe later on you evolved to be able to attack other bacteria and have to decide if attacking a colony in front of you will be easy or if they might be dangerous to yourself.
Here come the different #imaging and #staining techniques in #microscopy into play.
Instead of what is typical in a #firstperson #shooter to switch to #nightvision or #thermalvision you switch between different staining methods to visualize all the hidden detail of this world.
You switch the visualization to a #negativestain and see that the bacteria in the colony all have a unstained capsule around them and you havent evolved the ability to break down the thick peptidoglycan yet.
But you did evolve the skill of horizontal gene transfer and could search for friendly bacteria close by that could share that ability with you.
up the ladder you evolve by symbiosis and might gain your first organelles that allow you to become light sensitive.
maybe this leads you to a path where you decide to use light as main energy source instead of other bacteria or cellular debris.
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#gamedesign #science #research #biology
Do you remember the 2008? #game #spore that lets you play with #evolution starting as a #protozoa and you play to evolve to landfall and later space?
Like back then i still feel the only great part of this game is in fact the top down view playing your single celled organism, but i also feel it falls utterly short.
2008 was long before i became a #microscopy nerd and before i learned about #medical #microbiology .
What i love about microbiology and microscopy is that its such an alien world that allows for endless magical discovery. Where a single cell is alive and buzzing like a whole city with complex dynamics and the view through a microscope that looks visually just stunning and so vivid that no game #graphics can actually compete with it.
The game is there already, complex and alive, all around us.
Imagine a top down view just like the view through the microscope. Bright white background. you start as a single most basic bacterium. Invisible, of course. Here come different imaging and staining techniques into play.
Its an #RPG and you #levelup your bacterium. You eat, grow and evolve with a skill tree that reflects scientifically accurate abilities. evolve to break down cellulose for food, evolve a outer cell membrane and become a #grampositive bacterium for increased protection, evolve to build out spores so if you die you can get revived, evolve to build out a flagellum for motility and speed. (post goes on in replies)
#gamedesign #science #research #biology
Job - Alert
RESEARCH ASSISTANT / PHD STUDENT (ALL GENDERS) - DIVERSITY AND ECOLOGY OF VAMPIRE AMOEBAE
Deadline: 2025-06-15
Location: Germany, Darmstadt, Hessen
Job - Alert
RESEARCH ASSISTANT / PHD STUDENT (ALL GENDERS) - BEHAVIOUR AND CHEMICAL ECOLOGY
Deadline: 2025-06-15
Location: Germany, Darmstadt, Hessen
https://www.europesays.com/2095369/ Cell Painting technology uncovers flavonoids with potential to treat bladder cancer #america #Bladder #BladderCancer #cancer #Cell #CellularBiology #DNA #drugs #medicine #Microscopy #research #running #science #technology #UnitedStates #UnitedStatesOfAmerica #US #USA
A newly developed multiplane structured illumination #microscopy (#SIM) system achieves an 8× increase in volumetric imaging speed, capturing rapid interactions within live cells. Learn more: https://ilphotonics.com/live-cell-super-resolution-imaging-with-fast-3d-sim/
The Electron Microscope’s Canadian Link
Physicist Eli Burton and his University of Toronto team developed one of North America’s first electron microscopes in 1938, revolutionizing our ability to see the microscopic world.
#Canada #ScienceHistory #Microscopy
https://www.thecanadianencyclopedia.ca/en/article/eli-franklin-burton
Lovely work from Saravanan and colleagues, they insert the 13aa alfa tag into actin and then use an Alexa-nanobody to monitor actin in expansion microscopy in yeast and human cells. This is an excellent tool for actin research, and the general principle can be applied to a variety of other proteins.
The Duke Mouse #Brain Atlas: #MRI and light sheet #microscopy stereotaxic atlas of the mouse brain
3D Stereotaxic Atlas of the whole brain at microscopic scale https://www.science.org/doi/10.1126/sciadv.adq8089
Things I woke up thinking about: Tinnitus, 1.32na Condenser, Neurons-degenerating!!! https://t.me/micronicle0001/175
#Science #Microscopy #Neurology
A mite of some kind (unidentified) that I found walking across the laptop LCD panel in the home micronicle LAB...
Leitz 4x/12.5x Polarised Darkfield
#Science #Biology #Entomology #Arachnology #Microscopy
https://t.me/micronicle0000/1123
If you would like to attend a microscopy or bioimage analysis training course in the next 6 months but don’t have funding, check out our Microscopy Training Grant from @J_Cell_Sci and @focalplane_jcs.
Next deadline: 6 June 2025
https://www.biologists.com/grants/jcs-focalplane-training-grants/
Super excited to share my first 3D design! The SlideDock makes viewing microscope slides with USB microscopes SO much better - stable & clear! #3DPrinting #DIYMicroscope #Microscopy #FirstDesign #SlideDock
About time we get this #nakeddiefriday going, friends.
Today's exhibit is one ST1305B, by ST Micro. This is a memory card IC with 192 bits of memory on the die.
The die itself is only 1.40×1.18 mm, quite on the small side.
SiPron page: https://siliconpr0n.org/archive/doku.php?id=infosecdj:st:st1305b
A short thread follows.
Looking for new collaborations, organising speakers for a conference, or assembling a committee?
Join the @focalplane_jcs network, a directory of international researchers with microscopy expertise.
Arrived at the Volume Electron Microscopy
Gordon Research Conference
https://www.grc.org/volume-electron-microscopy-conference/2025/
near Barcelona. I will speak about Volume EM and #connectomics in marine zoomplankton.
I have a question about image processing. I took images with the same magnification and zoom. I rotated and cropped them in FIJI and added scale bars. The scale bar on one of the images is longer than the others. What is going on. I am literally about to lose it. I appreciate any advice.#microscopy #FIJI#science