#Senescent cells have been implicated in a variety of processes typically connected with #deterioration and #aging. Recent studies suggest that the short-term presence of senescent cells can actually be beneficial.
#Biology #sflorg
https://www.sflorg.com/2023/10/bio10272301.html

#TissueDamage induces spatially distinct patterns of #senescent & #proliferative cell behaviors; this allocates distinct cellular tasks required for tissue repair, driven by mutual repression between JNK/AP-1 & JAK/STAT signaling @classenlab #PLOSBiology https://plos.io/43dDU1z

Benefits of 'zombie' cells: Senescent cells aid regeneration in salamanders.

https://phys.org/news/2023-04-benefits-zombie-cells-senescent-aid.html
#news #senescent #longevity #aging

#Scientists show that so-called #senescent #cells, i.e., cells that have permanently stopped dividing, boost production of new #muscle cells to enhance regeneration of lost limbs in #salamanders. (#Zombie cells)
#Biology #sflorg
https://www.sflorg.com/2023/04/bio04142301.html

TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers

Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241