@wendigo Double-check that the tunnel configuration including key pair, port numbers and IP address is correct and current. I think Proton makes you re-download those from time to time (quite possibly for key rotation if nothing else).
That the wg0 tunnel interface shows up is no guarantee that the tunnel itself is working. One of the less nice things about Wireguard; you get no obvious "thing X is wrong" error when bringing the tunnel up if something isn't up to snuff.