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#ECM

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Ended the week and started the weekend with Promontoire by Benjamin Moussay, released on ECM in 2020.

Tyran Grillo wrote for ECM Reviews:

"After multiple appearances as sideman for Louis Sclavis, the timely Characters on a Wall most recent among them, pianist Benjamin Moussay for quietly dominates the marquee of an ECM album cover. In this program of original solo material, he shows himself to be a genuinely focused player who values not only melodies but also the spaces in which they breathe. What began as more fully fledged compositions have grown more open-ended over time, whittled away to whispering motifs and suggestive chords.

Our introduction to Moussay’s sound percolates through the boulders of “127.” Inspired by 127 Hours, the 2010 biopic about Aron Ralston’s harrowing escape from Bluejohn Canyon, it comes to us fully formed.."

ecmreviews.com/2020/06/01/benj

youtube.com/watch?v=zWypnbqBbu

📰 "A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction"
biorxiv.org/content/10.1101/20 #Mechanotransduction #Force #Cell #Ecm

bioRxiv · A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated MechanotransductionChronic lung injury generates metaplasia which occasionally, but ominously, progresses to squamous dysplasia and squamous lung cancer. To identify mechanisms through which disrupted tissue homeostasis contributes to malignant initiation and progression, we used in vivo and in vitro heterotypic recombinant models of human bronchial epithelial cells (hBECs) and fibroblasts. We demonstrate that injury-associated TGF-β signaling creates a fibroblast state dependent upon HSP47 upregulation. These fibroblasts accumulated collagen, thus elevating tissue stiffness and activating mechanosignaling that sustained YAP-dependent embryonic-like, pro-malignant activities in adjacent hBECs. This Stress/Tension-Instructive Fibroblast (STIF) state, exhibited by stressed fibroblasts in premalignant and malignant lesions across multiple cancer types, was sufficient to reprogram disease-free hBECs to metaplasia and to drive hBECs with compromised tumor suppressor function to dysplasia, yet could be inhibited and reversed. STIFs suffice to activate epithelial phenotypes reminiscent of oncogene-mediated cell transformation and induce (pre)malignancy via increased force transmission, providing novel targets for prevention. ### Competing Interest Statement The authors have declared no competing interest. Cancer Research UK, 27145, 29071, 29078, 29068 National Cancer Institute, https://ror.org/040gcmg81, 5R35CA197694, 5R50CA211543

📰 "ECM (collagen) mediated signaling drives the emergence of androgen independence in prostate cancer cells"
biorxiv.org/content/10.1101/20 #Extracellular #Mechanical #Ecm

bioRxiv · ECM (collagen) mediated signaling drives the emergence of androgen independence in prostate cancer cellsThe extracellular matrix is a dynamic entity that undergoes continuous deposition, remodeling, and degradation to maintain tissue homeostasis. As a major structural component of the tumor microenvironment, the ECM plays crucial roles in providing mechanical support, modulating the microenvironment, and serving as a reservoir for signaling molecules. Tissue stiffness is primarily determined by the abundance and cross-linking of the ECM components. Collagen is one of the major components of ECM and contributes to 30% of the total ECM. Increased collagen deposition contributes to enhanced tissue stiffness and is associated with a more aggressive cancer phenotype. A restructured ECM, particularly collagen content, can influence cellular signaling pathways through interaction with cell surface receptors. In the current study, we investigated the role of collagen in prostate cancer. Our findings indicate that collagen, a major component of the TME, modulates prostate cancer cell migration, alters sensitivity to chemotherapeutic agents, and promotes non-genomic activation of androgen receptor signaling through FAK activation, thereby contributing to therapy (androgen deprivation therapy) resistance and cancer progression. ### Competing Interest Statement The authors have declared no competing interest.

Ended the weekend and welcomed the working week after a swim with Surrounded by Sea an album by British saxophonist and composer Andy Sheppard recorded in Switzerland in 2014 and released on the ECM label the following year.

Tyran Grillo wrote for ECM reviews:

"Surrounded by Sea marks the fifth ECM appearance by English saxophonist Andy Sheppard. To the configuration of bassist Michel Benita and drummer Sebastian Rochford (with whom he previously recorded as Trio Libero) he now welcomes the ambient touch of guitarist Eivind Aarset. The latter, perhaps more than any other, evokes the encompassing waters of the album’s title, and draws on the relationship formed on Sheppard’s ECM debut, Movements in Colour.

Emphasis sides with Sheppard’s compositions, which have the first and final word on Surrounded by Sea. “Tipping Point,” co-written with Benita, opens the set on a distant shore.."

ecmreviews.com/2015/08/31/surr

youtube.com/watch?v=jyrn9zKMbp

Ended the week and welcomed the weekend with Trio Libero an album by British saxophonist and composer Andy Sheppard recorded in Switzerland in July 2011 and released on ECM in January the following year

The level of comfort shared by saxophonist Andy Sheppard, bassist Michel Benita, and drummer Sebastian Rochford bears out from the first moments of opener “Libertino” with a looseness that never loses sight or hold of things..Under guise of balladry, “When We Live On The Stars…” concludes with a promise that the people and pleasures we adore will still be waiting for us when we wake.

Nowhere within these relatively brief tunes will you find demonstrative solos or waving of virtuosic flags. That said, it requires a special kind of virtuosity to carry off such music so humbly, and with a spirit that is as naked as the day all of us were born. This is the art of the trio, liberated."

ecmreviews.com/2014/10/02/trio

youtube.com/watch?v=5H53Vm2n0P

Welcomed sleep and greeted the new day after my swim with Romaria an album by the Andy Sheppard Quartet recorded in Switzerland in April 2017 and released on ECM February the following year. The quartet features rhythm section Eivind Aarset, Michel Benita and Sebastian Rochford.

Saxophonist Andy Sheppard’s quartet with guitarist Eivind Aarset, bassist Michel Benita and drummer Sebastian Rochford pulls out threads from this album’s predecessor and from them weaves an even more seamless tapestry.

Once again, Aarset proves an integral presence, adding (in Sheppard’s words) an “orchestral voice,” which percolates as life-giving water through soil..."

ecmreviews.com/2019/03/08/andy

youtube.com/watch?v=h82CE9x6-9

X) Whether #IgnitionKey is #switchon, #switchoff, as long as the #carbattery is still connected, some #controlunit's still 'kinda' be powered🤷!

Could be the #BCM for the body, #ECM for engine or whichever🤷, depending on the #controlsystem as this👇 rubbish demonstrates #ecu nonsense👇

www.5021.tips/ujanja/ecu3

👆
If with time & data to waste, #HapaUjanjaTu just #teachyourself #howitworks #howitsmade #howtorepair #controlsystems #autoelectronics #ecurepair #repairtips #5021tips #autorepairtips

This morning's Father's Day #workout #music is from Terje Rypdal ( #Guitar ); Miroslav Vitous ( #Bass ); & Trilok Gurtu - ( #Percussion ) - Gurtu's trap set really is unique and is fascinating to see his #tabla chops translated to western beats.

youtu.be/VRd2_0JdnNA
#jazzFusion #drummer #ECM #RowingMachine #Calisthenics

youtu.be- YouTubeEnjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Slipped into sleep and then welcomed Friday with Cycles the second album by cellist David Darling, recorded in 1981 and released on ECM the following year.

Tyran Grillo wrote for ECM Reviews:

"Cellist David Darling has had a long, if sporadic, association with ECM, quietly forging—either under the guise of solo artist or buried in an album’s roster—some of the label’s most lyrical atmospheres. With Cycles, however, Darling magnified his sound-world through the inimitable talents of Jan Garbarek and Collin Walcott in a space both selfless and uniquely his own. Add to that the astonishing pianism of Steve Kuhn and the depth of Arild Andersen on bass, and you get what is, to this listener at least, one of ECM’s finest celestial alignments..."

ecmreviews.com/2011/11/08/cycl

youtube.com/watch?v=S0zxDklTW7

Yellow Fields is an album by German double bassist and composer Eberhard Weber recorded in September 1975 and released on ECM the following year. The quartet features saxophonist Charlie Mariano, pianist Rainer Brüninghaus and drummer Jon Christensen.

The Penguin Guide to Jazz awarded it the maximum four stars and placed it in their Core Collection, writing "Weber's masterpiece is essentially a period piece which nevertheless still seems modern. The sound of it is almost absurdly opulent: bass passages and swimming keyboard textures that reverberate from the speakers, chords that seem to hum with huge overtones. The keyboard textures in particular are of a kind that will probably never be heard on record again." - Wikipedia

youtube.com/watch?v=1Z_K-_uARQ

Ended the weekend and greeted the week after a swim with Life Goes On by Carla Bley, Andy Sheppard and Steve Swallow, released on ECM in 2020

Tyran Grillo wrote for ECM Reviews:

"For its third ECM outing, pianist Carla Bley’s trio with saxophonist Andy Sheppard and bassist Steve Swallow mixes up an antidote for these times of uncertainty and quarantine. The title suite is the first of three comprising the program. Given that “Life Goes On” came out of a recent brush with illness, it’s fitting that Bley should begin in the dark whimsy of the blues. Her left hand plows fertile soil before leaving Sheppard and Swallow to sow their thematic crop. Years of experience and collaboration funnel into Swallow’s intimate rapport with Bley and into Sheppard’s unforced, spiritual playing. The latter, whether breathing through tenor or soprano, takes two steps forward for every retreat.."

ecmreviews.com/2020/05/02/bley

youtube.com/watch?v=tz0_l3maHG