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#lifetime

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The vOICe vision BCI 🧠🇪🇺

Long-term performance of intracortical microelectrode arrays in 14 BrainGate clinical trial participants medrxiv.org/content/10.1101/20 Utah array, #BCI #NeuroTech #longevity #lifetime

medRxiv · Long-term performance of intracortical microelectrode arrays in 14 BrainGate clinical trial participantsBrain–computer interfaces have enabled people with paralysis to control computer cursors, operate prosthetic limbs, and communicate through handwriting, speech, and typing. Most high-performance demonstrations have used silicon microelectrode "Utah" arrays to record brain activity at single neuron resolution. However, reports so far have typically been limited to one or two individuals, with no systematic assessment of the longevity, decoding accuracy, and day–to–day stability properties of chronically implanted Utah arrays. Here, we present a comprehensive evaluation of 20 years of neural data from the BrainGate and BrainGate2 pilot clinical trials. This dataset spans 2,319 recording sessions and 20 arrays from the first 14 participants in these trials. On average, arrays successfully recorded neural spiking waveforms on 35.6% of electrodes, with only a 7% decline over the study enrollment period (up to 7.6 years, with a mean of 2.8 years). We assessed movement intention decoding performance using a "decoding signal-to-noise ratio" (dSNR) metric, and found that 11 of 14 arrays provided meaningful movement decoding throughout study enrollment (dSNR > 1). Three arrays reached a peak dSNR greater than 4.5, approaching that achieved during able-bodied computer mouse control (6.29). We also found that dSNR increases logarithmically with the number of electrodes, providing a pathway for scaling performance. Longevity and reliability of Utah array recordings in this study were better than in prior nonhuman primate studies. However, achieving peak performance consistently will require addressing unknown sources of variability. ### Competing Interest Statement The MGH Translational Research Center has a clinical research support agreement (CRSA) with Ability Neurotech, Axoft, Neuralink, Neurobionics, Paradromics, Reach Neuro, Precision Neuro, and Synchron, for which LRH provides consultative input. LRH is a non-compensated member of the Board of Directors of a nonprofit assistive communication device technology foundation (Speak Your Mind Foundation). Mass General Brigham (MGB) is convening the Implantable Brain-Computer Interface Collaborative Community (iBCI-CC); charitable gift agreements to MGB, including those received to date from Paradromics, Synchron, Precision Neuro, Neuralink, and Blackrock Neurotech, support the iBCI-CC, for which LRH provides effort. FRW is an inventor on intellectual property licensed by Stanford University to Blackrock Neurotech and Neuralink Corp. JPD is a Director and shareholder in Pathmaker Neurosystems and a shareholder in Beacon Biosignals. All other authors have no competing interests. ### Clinical Trial NCT00912041 ### Funding Statement This work was supported by Office of Research and Development, Department of Veterans Affairs (N2864C, N9228C, A4820R, A2295R, B6453R, B6459L, A6779L, P1155R, A2827R,A3803R), NIH NIDCD (R01DC009899), NIH NIDCD (U01DC017844), NIH NIDCD(R01DC014034), NIH NIDCD (U01DC019430), NIH NICHD-NCMRR (N01HD53403), NIH NICHD-NCMRR (N01HD10018), NIH NICHD-NCMRR (R01HD077220), NIH NINDS,(U01NS098968), NIH NINDS (U01NS062092), NIH NINDS (UH2NS095548), NIH NINDS(U01NS123101), NIH NICHD (RC1HD063931), Simons Foundation (543,045), Howard Hughes Medical Institute, Doris Duke Charitable Foundation, Conquer Paralysis Now (004698), AHA (19CSLOI34780000), ALS Association (20-MALS-553), Larry and Pamela Garlick, Samuel and Betsy Reeves, MGH-Deane Institute, The Executive Committee on Research (ECOR) of Massachusetts General Hospital, Wu Tsai Neurosciences Institute, Bio-X Institute at Stanford, Robert J. and Nancy D. Carney Institute for Brain Science, Brown University School of Engineering, Brown University Office of the Vice President for Research ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The IRB of Stanford University, IRB of Mass General Brigham, IRB of Case Western Reserve University and the IRB of Providence VA Healthcare gave ethical approval for this work I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data required to reproduce these results will be publicly released upon acceptance in a peer-reviewed journal.
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zimbi

Ich hab zwar etliche Händler gefunden, die die Dinger verkaufen, aber keine Ersatzteile. Also den #support kontaktiert wo in #EU ich Ersatzteile bestellen kann. Der Support hat ir nett mitgeteilt, das das aktuell noch nicht geht. Sie waren sehr hilfreich bei der Identifikation des fehlenden Teils und haben es mir kostenfrei inkl. Versand aus #USA geschickt. Chapeau #Lifetime!
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zimbi

Ich muß jetzt mal was los werden. Wir haben einen #Komposter von #Lifetime und beim Leeren habe ich ein Verbindungsstück aus der Ecke gehauen. Das Teil hat sich im dahinter liegenden Gebüsch versteckt und lies sich nicht mehr auffinden.
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