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#h5n6

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#Genetic #diversity of highly pathogenic avian #influenza #H5N6 and #H5N8 viruses in #poultry #markets in #Guangdong, #China, 2020-2022

Source: Journal of Virology, ABSTRACTH5 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/96 (Gs/Gd) lineage continue to evolve and cause outbreaks in domestic poultry and wild birds, with sporadic spillover infections in mammals. The global spread of clade 2.3.4.4b viruses via migratory birds since 2020 has…

etidioh.wordpress.com/2024/12/

ETIDIoH · #Genetic #diversity of highly pathogenic avian #influenza #H5N6 and #H5N8 viruses in #poultry #markets in #Guangdong, #China, 2020-2022
More from ETIDIoH

#Epidemiological characterization of #human #infection with #H5N6 avian #influenza

Source: Frontiers in Public Health, Abstract Background: In recent years, there have been frequent reports of human infection with H5N6 avian influenza. However, the fundamental characteristics of the disease remain unclear. This paper conducts a systematic review to explore the epidemiological features of the disease, aiming to provide a foundation for epidemic prevention and control…

etidioh.wordpress.com/2024/10/

ETIDIoH · #Epidemiological characterization of #human #infection with #H5N6 avian #influenzaSource: Frontiers in Public Health, Abstract Background: In recent years, there have been frequent reports of human infection with H5N6 avian influenza. However, the fundamental characteristics of …

Farmed #fur #animals harbour #viruses with #zoonotic #spillover potential, Nature: nature.com/articles/s41586-024

We identified 7 species of #coronaviruses, expanding their known host range, & documented cross-species transmission of a novel #canine respiratory coronavirus to raccoon dogs & of #bat HKU5-like CoV to #mink, present at a high abundance in lung tissues. 3 subtypes of #influenza A virus—#H1N2, #H5N6 & #H6N2—were detected in #lungs of guinea pig, mink and #muskrat, respectively.

NatureFarmed fur animals harbour viruses with zoonotic spillover potential - NatureFur farming represents an important hub of cross-species transmission for viral zoonoses.

#Influenza at #human - #animal interface - #Summary and #risk #assessment, from 8 June to 19 July 2024, #WHO: cdn.who.int/media/docs/default

New human cases: From 8 June to 19 July 2024, the detection of influenza A(#H5) virus in four humans, #H5N1 in 3 humans, #H5N6 in 1 human, and #H9N2 in 1 human were reported officially. Additionally, the detection of H1N2 variant #H1N2v virus in 2 humans was reported.

#Influenza at the #human - #animal #interface, #summary and #assessment, 7 June 2024 - From 4 May to 7 June '24, release date 7 June '24, section: Emergency Situational Updates, #WHO: who.int/publications/m/item/in

From 4 May to 7 June '24, 4 human cases of infection with influenza #H5N1 viruses, 1 case of #H5N2 virus, 2 cases of #H5N6 viruses, & 3 cases of #H9N2 viruses were reported officially.

www.who.intInfluenza at the human-animal interface summary and assessment, 7 June 20244 May to 7 June 2024

#COBRA #HA and #NA #vaccination elicits long-live protective immune responses against pre-pandemic #H2, #H5, and #H7 #influenza virus subtypes, Virology: sciencedirect.com/science/arti

Multivalent vaccine was evaluated in both naïve & pre-immune mice to mimic immunity in humans. Both HA head- & stem-directed Abs levels were high in vaccinated mice. Little to no #lung #injury was observed in lungs of vaxed mice following challenge. Vaccine provided 4-mos-long protection vs clade 2.3.4.4 #H5N6 virus.

Fatal case of avian influenza A(H5N6) in Fujian, China (via UNMC). 👀

"52-year-old female living in Quanzhou city in Fujian Province, who had exposure to backyard poultry before the onset of symptoms. She developed symptoms on April 13 and was admitted to a hospital for treatment on April 20. She passed away on April 30."

unmc.edu/healthsecurity/transm

Novel Avian #Influenza A(#H5N6) in Wild #Birds, South #Korea, 2023, Emerg Infect Dis.: wwwnc.cdc.gov/eid/article/30/6

H5N6 viruses possessed molecular #markers T188, V210, Q222, & G224 in HA, are associated with binding affinity to α-2,3 SA receptors. S133A & T156A in HA, known to be associated with increased binding to α-2,6 SA receptors. L89V in PB2, but not Q591K, E627K, and D701N. D622G in PB1, N30D & I43M in M1, & P42S in NS1, associated with increased virulence in mice.

Emerging Infectious Diseases journalNovel Avian Influenza A(H5N6) in Wild Birds, South Korea, 2023Novel Avian Influenza A(H5N6) in Wild Birds, South Korea, 2023