Revolutionizing genetics: Dana-Farber's 'Perturb-multiome' tool deciphers cellular programming, unlocking new potentials in blood disorder therapies. #Genomics #CRISPR #BloodDisorders

Revolutionizing genetics: Dana-Farber's 'Perturb-multiome' tool deciphers cellular programming, unlocking new potentials in blood disorder therapies. #Genomics #CRISPR #BloodDisorders
How #genome-wide sequence divergence maps to species status https://www.pnas.org/doi/10.1073/pnas.2319389122 #biodiversity #genomics
More on #genomics, this is obviously crazy since the #world's #genetic #diversity is contained within #Africa. Yet African DNA is underrepresented! Oh dear, it should not be only African scientists noticing this.
'African scientists say the world is missing vital medical insights by ignoring the continent’s vast genetic diversity. Less than 2 percent of human genome sequencing worldwide comes from African populations.'
EBV's sneaky genetic dance with MS revealed! Viral genes play puppet master in autoimmune drama
Groundbreaking insights into virus-disease connections. #Genomics #MedicalResearch #Virology https://emmecola.github.io/genomics-daily
#Genetic data site #openSNP to close and delete data over #privacy concerns
openSNP, a platform for sharing genetic and phenotypic data, will shut down, and delete all user submissions over privacy concerns and risk of misuse by authoritarian governments.
Announced earlier this week by co-founder Bastian Greshake Tzovaras, who expressed concerns about how personal #genomics data is subject to abuse today and how fundamentally landscape has changed over the last 14 years.
https://www.bleepingcomputer.com/news/security/genetic-data-site-opensnp-to-close-and-delete-data-over-privacy-concerns/
The European Reference Genome Atlas (ERGA) is a community initiative coordinating the production of a reference #genome for all eukaryotic species in Europe. https://en.wikipedia.org/wiki/European_Reference_Genome_Atlas #Biodiversity #Genomics
Can AI predict DNA structures better than traditional methods?
This study benchmarks DNA large language models (LLMs) in identifying G-quadruplexes (G4s)—special DNA structures linked to gene regulation, cancer, and therapeutics.
Benchmarking DNA large language models on quadruplexes. Computational and Structural Biotech Journal, DOI: https://doi.org/10.1016/j.csbj.2025.03.007
CSBJ: https://www.csbj.org
[biological evolution] Whole-genome duplication drives long-term adaptation
https://www.sciencedaily.com/releases/2025/03/250326221649.htm
https://news.ycombinator.com/item?id=43515443
Genome duplication in a long-term multicellularity evolution experiment
https://www.nature.com/articles/s41586-025-08689-6
Cracking the CHD code! 60 genes linked to congenital heart disease reveal hidden genetic mysteries. Molecular diagnostics FTW!
#Genomics #MedicalBreakthrough #Genetics https://emmecola.github.io/genomics-daily
The mitch R/Bioconductor package for enrichment analysis gets new network visualisation function in the devel branch. See these examples for how lung cells respond to C19 infection. Here red=up regulated, blue=down.
Details and quickstart guide: https://genomespot.blogspot.com/2025/04/mitch-gets-upgraded-now-with-gene-set.html
#Genomics #Bioinformatics #dataviz
#Genetics #Genomics #Cancer #Academia #AcademicChatter
Interested in cancer genetics? Don't want to fly somewhere to here about it? Next week the American Society of Human Genetics is having an online-only digital symposium on cancer genetics.
https://www.ashg.org/product/2025-spring-symposium-emerging-frontiers-in-cancer-genetics/
I think it's also worth up to 6 #CME credits if you do continuing medical education.
We have a 4-year PhD position available in the Slotte lab at Stockholm University, to investigate genomic signatures of selection associated with pollination mode shifts.
Full ad: https://su.varbi.com/en/what:job/jobID:805144/where:4/
Apply by April 22, 2025 via the University application portal. Please repost! #stockholm #evolgen #evolution #genomics #phdPosition
Genome Editing and Therapeutics - Faculty
Mount Sinai
See the full job description on jobRxiv: https://jobrxiv.org/job/mount-sinai-27778-genome-editing-and-therapeutics-faculty/?feed_id=93797
#genetics #genome_modelling #genomics #therapeutic_targets #ScienceJobs #hiring #research
https://jobrxiv.org/job/mount-sinai-27778-genome-editing-and-therapeutics-faculty/?feed_id=93797
Another ‘scandal - but the wrong one! The real one is that Irish public money founded the acquisition of genetic information and then its transfer to the US - where as has become obvious, a group of pirates who could not give a shit about people are ‘managing’ privacy and the judiciary.
Correction - added link to news archive
This study explores how nanopore sequencing transforms biochemical molecules into human-readable signals—revolutionizing how we decode protozoan genomes.
Nanopore sequencing of protozoa: Decoding biological information on a string of biochemical molecules into human-readable signals. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.01.002
CSBJ: https://www.csbj.org/
#Genomics
#Bioinformatics
#Academia
Beware US academic coders. If you have collaborators contributing code from a sanctioned region, your repos may be locked.
See https://mastodon.social/@organicmaps/114155428924741370
The kicker is that the US is leaning authoritarian and all in on censorship. If Canada or Mexico become sanction targets and you have code pushes from there, Microsoft will lock you out of your GitHub accounts.
How is there so much variation in cost between different sequencing providers #genomics
Want to improve your genomic variant calling pipeline? Join our webinar to learn about ncbench, a powerful benchmarking tool. We'll also cover other essential genomic benchmarking topics. Register for free: https://t1p.de/o4al3 #bioinformatics #genomics #variantcalling #ncbench
Alexandros Stamatakis' annual EMBO satellite #bioinformatics workshop in Crete is open again for registration (free-of-charge, first-come-first-serve)
This year: #biodiversity #genomics tools
https://forms.gle/GRvPxCp2TnYdo8Po8
As Alexi is keen to point out: "... a good excuse to visit Crete?"